Differential Effects of DNA Double-Strand Break Repair Pathways on Single-Strand and Self-Complementary Adeno-Associated Virus Vector Genomes
نویسندگان
چکیده
منابع مشابه
Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.
The linear DNA genomes of recombinant adeno-associated virus (rAAV) gene delivery vectors are acted upon by multiple DNA repair and recombination pathways upon release into the host nucleus, resulting in circularization, concatemer formation, or chromosomal integration. We have compared the fates of single-strand rAAV (ssAAV) and self-complementary AAV (scAAV) genomes in cell lines deficient in...
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1.1 Induction and repair of double-strand breaks (DSBs) in the DNA DNA encodes and transmits genetic information into the progeny of cells and organisms. As a result, processes associated with DNA replication, repair and recombination are at the center of biological research. Although the double-stranded nature of the DNA molecule is not a requirement for its replication or transcription, it is...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2010
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.00641-10